Criteria for safety evaluation of antimicrobial agents
نویسندگان
چکیده
منابع مشابه
Developing safety criteria for introducing new agents into neoadjuvant trials.
New approaches to drug development are critically needed to lessen the time, cost, and resources necessary to identify and optimize active agents. Strategies to accelerate drug development include testing drugs earlier in the disease process, such as the neoadjuvant setting. The U.S. Food and Drug Administration (FDA) has issued guidance designed to accelerate drug approval through the use of n...
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In a recent article, Dagan et al. (1) report on the comparative bacteriologic efficacies of oral azithromycin and oral cefaclor in children with acute otitis media. The authors assert that based on a double-tympanocentesis method of evaluating bacteriologic eradication in otitis media susceptibility breakpoints for antibiotics can be determined and previous clinical efficacy studies are inadequ...
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The condensation reaction of 5-(4-aminophenyl)-4-phenyl-1,2,4-triazole-3-thione with salicylaldehyde, 4-hydroxybenzaldehyde, 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde, 2-nitrobenzaldehyde, 3-nitrobenzaldehyde, 4-nitrobenzaldehyde and 4-methoxybenzaldehyde in methanol results in series of new Schiff bases. The structure of Schiff bases were confirmed by 1H NMR, 13C NMR, IR and mass spectro...
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Objective: Tribes in Nubia Mountains regions of Sudan used Monechma ciliatum seeds for common cold and other chest allergic conditions as a traditional medicine. The aim of this paper is to validate this traditional practice scientifically. Materials and Methods: Monechma ciliatum seeds were screened for major phytochemical groups using standard methods. Different extracts were bioassayed in- v...
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ژورنال
عنوان ژورنال: Journal of Infection and Chemotherapy
سال: 2011
ISSN: 1341-321X
DOI: 10.1007/s10156-010-0183-0